9tlw: Difference between revisions
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==De novo designed single-chain antiparallel coiled-coil hairpin with binding site for MCL-1, Sc-apCC-2-MCL-1-4 in complex with MCL-1== | |||
<StructureSection load='9tlw' size='340' side='right'caption='[[9tlw]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9tlw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TLW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tlw OCA], [https://pdbe.org/9tlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tlw RCSB], [https://www.ebi.ac.uk/pdbsum/9tlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tlw ProSAT]</span></td></tr> | ||
[[Category: Acevedo-Jake | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Acevedo-Jake A]] | |||
[[Category: Mylemans B]] | |||
[[Category: Wilson AJ]] | |||
[[Category: Woolfson DN]] | |||
Latest revision as of 05:05, 19 August 2026
De novo designed single-chain antiparallel coiled-coil hairpin with binding site for MCL-1, Sc-apCC-2-MCL-1-4 in complex with MCL-1
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