9xv1: Difference between revisions
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==Crystal Structure of Fructose-1,6-bisphosphatase Complexed with a Covalent Inhibitor== | |||
<StructureSection load='9xv1' size='340' side='right'caption='[[9xv1]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9xv1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XV1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1E1G:2-bromanyl-~{N}-[2-[4-[(3-phenylphenyl)carbamoylsulfamoyl]phenyl]ethyl]ethanamide'>A1E1G</scene></td></tr> | ||
[[Category: Cao | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xv1 OCA], [https://pdbe.org/9xv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xv1 RCSB], [https://www.ebi.ac.uk/pdbsum/9xv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xv1 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: Hu | [https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] | ||
[[Category: Zhang | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cao H]] | |||
[[Category: Chang M]] | |||
[[Category: Chu Y]] | |||
[[Category: Hu X]] | |||
[[Category: Huang Z]] | |||
[[Category: Li W]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 05:31, 24 December 2025
Crystal Structure of Fructose-1,6-bisphosphatase Complexed with a Covalent Inhibitor
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