9yso: Difference between revisions
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==Human DCTPP1 bound to a Class II inhibitor== | |||
<StructureSection load='9yso' size='340' side='right'caption='[[9yso]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9yso]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YSO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C0D:(6-methoxypyridin-3-yl)-[(3~{S})-3-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)-1,2,3-triazol-1-yl]piperidin-1-yl]methanone'>A1C0D</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr> | ||
[[Category: Berger | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yso OCA], [https://pdbe.org/9yso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yso RCSB], [https://www.ebi.ac.uk/pdbsum/9yso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yso ProSAT]</span></td></tr> | ||
[[Category: Hauk | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DCTP1_HUMAN DCTP1_HUMAN] Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.<ref>PMID:24467396</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Berger JM]] | |||
[[Category: Hauk G]] | |||
Revision as of 15:22, 10 June 2026
Human DCTPP1 bound to a Class II inhibitor
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