1x5v: Difference between revisions

Line 1:

[[Image:1x5v.~~gif~~|left|200px]]

[[Image:1x5v.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~NMR Structure of PcFK1~~'''~~

===NMR Structure of PcFK1===

~~==Overview==~~

<!--

~~Psalmopeotoxin I (PcFK1) is a 33~~-~~amino~~-acid residue peptide isolated from the venom of the tarantula Psalmopoeus cambridgei. It has been recently shown to possess strong antiplasmodial activity against the intra-erythrocyte stage of Plasmodium falciparum in vitro. Although the molecular target for PcFK1 is not yet determined, this ~~peptide does not lyse erythrocytes~~, ~~is not cytotoxic to nucleated mammalian cells~~, ~~and does not inhibit neuromuscular function. We investigated~~ the ~~structural properties of PcFK1~~ to ~~help understand~~ the ~~unique mechanism of action of this peptide and to enhance its utility~~ as ~~a lead compound for rational development of new antimalarial drugs~~. ~~In this paper, we have determined the three-dimensional solution structure by (1~~)~~H two-dimensional NMR means of recombinant PcFK1~~, ~~which~~ is ~~shown to belong to~~ the ~~ICK structural superfamily with structural determinants common to several neurotoxins acting as ion channels effectors~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16452619}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16452619 is the PubMed ID number.

-->

==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA].

==Reference==

Line 27:

Line 31:

[[Category: Pimentel, C.]]

[[Category: Inhibitory cystine knot]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 14~~:36:00 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:51:59 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1x5v.gif|left|200px]]
+{{Seed}}
+[[Image:1x5v.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1x5v|  PDB=1x5v  |  SCENE=  }}
-'''NMR Structure of PcFK1'''
+===NMR Structure of PcFK1===
-==Overview==
+<!--
-Psalmopeotoxin I (PcFK1) is a 33-amino-acid residue peptide isolated from the venom of the tarantula Psalmopoeus cambridgei. It has been recently shown to possess strong antiplasmodial activity against the intra-erythrocyte stage of Plasmodium falciparum in vitro. Although the molecular target for PcFK1 is not yet determined, this peptide does not lyse erythrocytes, is not cytotoxic to nucleated mammalian cells, and does not inhibit neuromuscular function. We investigated the structural properties of PcFK1 to help understand the unique mechanism of action of this peptide and to enhance its utility as a lead compound for rational development of new antimalarial drugs. In this paper, we have determined the three-dimensional solution structure by (1)H two-dimensional NMR means of recombinant PcFK1, which is shown to belong to the ICK structural superfamily with structural determinants common to several neurotoxins acting as ion channels effectors.
+The line below this paragraph, {{ABSTRACT_PUBMED_16452619}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16452619 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16452619}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5V OCA].
 ==Reference==
@@ Line 27: / Line 31: @@
 [[Category: Pimentel, C.]]
 [[Category: Inhibitory cystine knot]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:36:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:51:59 2008''