2adb: Difference between revisions

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[[Image:2adb.gif|left|200px]]<br />

[[Image:2adb.gif|left|200px]]<br /><applet load="2adb" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2adb" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2adb" />

'''Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA'''<br />

==Overview==

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA, binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the, solution structures of the four RNA binding domains (RBDs) of PTB, each, bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different, binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel, orientation of their bound RNAs. Thus, PTB will induce RNA looping when, bound to two separated pyrimidine tracts within the same RNA. This leads, to structural models for how PTB functions as an alternative-splicing, repressor.

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.

==About this Structure==

2ADB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].

2ADB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Allain, F.H.T.]]

[[Category: Allain, F H.T.]]

[[Category: Auweter, S.D.]]

[[Category: Auweter, S D.]]

[[Category: Black, D.L.]]

[[Category: Black, D L.]]

[[Category: Erat, M.]]

[[Category: Hargous, Y.]]

[[Category: Henning, A.]]

[[Category: Oberstrass, F.C.]]

[[Category: Oberstrass, F C.]]

[[Category: Pitsch, S.]]

[[Category: Reymond, L.]]

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[[Category: rrm]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 20~~:49:~~14 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:26:12 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2adb.gif|left|200px]]<br />
+[[Image:2adb.gif|left|200px]]<br /><applet load="2adb" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2adb" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2adb" />
 '''Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA'''<br />
 ==Overview==
-The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA, binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the, solution structures of the four RNA binding domains (RBDs) of PTB, each, bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different, binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel, orientation of their bound RNAs. Thus, PTB will induce RNA looping when, bound to two separated pyrimidine tracts within the same RNA. This leads, to structural models for how PTB functions as an alternative-splicing, repressor.
+The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.
 ==About this Structure==
-ADB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].
+ADB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Allain, F.H.T.]]
+[[Category: Allain, F H.T.]]
-[[Category: Auweter, S.D.]]
+[[Category: Auweter, S D.]]
-[[Category: Black, D.L.]]
+[[Category: Black, D L.]]
 [[Category: Erat, M.]]
 [[Category: Hargous, Y.]]
 [[Category: Henning, A.]]
-[[Category: Oberstrass, F.C.]]
+[[Category: Oberstrass, F C.]]
 [[Category: Pitsch, S.]]
 [[Category: Reymond, L.]]
@@ Line 28: / Line 27: @@
 [[Category: rrm]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:49:14 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:26:12 2008''