9tlu: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 9tlu is ON HOLD until Paper Publication~~

==De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL==

~~Authors: Mylemans, B., Acevedo-Jake, A., Caulton, S.G., Edwards, T.A., Lovering, A.L., WIlson, A.J., Woolfson, D.N.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[9tlu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TLU FirstGlance]. <br>

~~Description:~~ De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99Å</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tlu OCA], [https://pdbe.org/9tlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tlu RCSB], [https://www.ebi.ac.uk/pdbsum/9tlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tlu ProSAT]</span></td></tr>

[[~~Category~~: ~~Wilson~~, A.J]]

</table>

[[~~Category~~: ~~Edwards~~, T.A]]

== Function ==

[[Category: ~~Lovering, A.L~~]]

[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>

[[Category: ~~Woolfson, D.N~~]]

== References ==

[[Category: ~~Mylemans, B~~]]

[[Category: Acevedo-Jake, A]]

__TOC__

[[Category: Caulton~~, S.G~~]]

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Synthetic construct]]

[[Category: Acevedo-Jake A]]

[[Category: Caulton SG]]

[[Category: Edwards TA]]

[[Category: Lovering AL]]

[[Category: Mylemans B]]

[[Category: WIlson AJ]]

[[Category: Woolfson DN]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9tlu is ON HOLD  until Paper Publication
+==De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL==
+<StructureSection load='9tlu' size='340' side='right'caption='[[9tlu]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
-Authors: Mylemans, B., Acevedo-Jake, A., Caulton, S.G., Edwards, T.A., Lovering, A.L., WIlson, A.J., Woolfson, D.N.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9tlu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TLU FirstGlance]. <br>
-Description: De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tlu OCA], [https://pdbe.org/9tlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tlu RCSB], [https://www.ebi.ac.uk/pdbsum/9tlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tlu ProSAT]</span></td></tr>
-[[Category: Wilson, A.J]]
+</table>
-[[Category: Edwards, T.A]]
+== Function ==
-[[Category: Lovering, A.L]]
+[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>   Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
-[[Category: Woolfson, D.N]]
+== References ==
-[[Category: Mylemans, B]]
+<references/>
-[[Category: Acevedo-Jake, A]]
+__TOC__
-[[Category: Caulton, S.G]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Acevedo-Jake A]]
+[[Category: Caulton SG]]
+[[Category: Edwards TA]]
+[[Category: Lovering AL]]
+[[Category: Mylemans B]]
+[[Category: WIlson AJ]]
+[[Category: Woolfson DN]]