2adu: Difference between revisions

[[Image:2adu.gif|left|200px]]<br />

<applet load="2adu" size="450" color="white" frame="true" align="right" spinBox="true"  

Inhibitors of human methionine aminopeptidase type 2 (hMetAP2) are of, interest as potential treatments for cancer. A new class of small molecule, reversible inhibitors of hMetAP2 was discovered and optimized, the, 4-aryl-1,2,3-triazoles. Compound 24, a potent inhibitor of, cobalt-activated hMetAP2, also inhibits human and mouse endothelial cell, growth. Using a mouse matrigel model, this reversible hMetAP2 inhibitor, was also shown to inhibit angiogenesis in vivo.

2ADU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CO and R20 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ADU OCA].  

[[Category: Fisher, P.W.]]

[[Category: Hansbury, M.J.]]

[[Category: Ho, T.F.]]

[[Category: Hofmann, G.A.]]

[[Category: Janson, C.A.]]

[[Category: Johanson, K.O.]]

[[Category: Johnson, R.K.]]

[[Category: Kallander, L.S.]]

[[Category: Kirkpatrick, R.B.]]

[[Category: Mattern, M.R.]]

[[Category: Meek, T.D.]]

[[Category: Ryan, M.D.]]

[[Category: Schulz-Pritchard, C.K.]]

[[Category: Smith, W.W.]]

[[Category: Thompson, S.K.]]

[[Category: Veber, D.F.]]

[[Category: Ward, K.W.]]

[[Category: Winkler, J.D.]]

[[Category: Zhang, G.F.]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:49:33 2007''