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'''Unreleased structure'''


The entry 22ha is ON HOLD
==The crystal structure of BRD4-BD1 in complex with inhibitor C2==
 
<StructureSection load='22ha' size='340' side='right'caption='[[22ha]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Wu, C.Y., Zhang, J.F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[22ha]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=22HA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=22HA FirstGlance]. <br>
Description: The crystal structure of BRD4-BD1 in complex with inhibitor C2
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1FFR:3-chloranyl-~{N}-(3,4-dimethoxyphenyl)-4-[[(1~{R},2~{S})-2-methyl-3-oxidanylidene-cyclopentyl]amino]benzamide'>A1FFR</scene></td></tr>
[[Category: Wu, C.Y]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=22ha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=22ha OCA], [https://pdbe.org/22ha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=22ha RCSB], [https://www.ebi.ac.uk/pdbsum/22ha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=22ha ProSAT]</span></td></tr>
[[Category: Zhang, J.F]]
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wu CY]]
[[Category: Zhang JF]]
Retrieved from "https://proteopedia.org/22ha"