1xax: Difference between revisions

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[[Image:1xax.gif|left|200px]]
{{Seed}}
[[Image:1xax.png|left|200px]]


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{{STRUCTURE_1xax|  PDB=1xax  |  SCENE=  }}  
{{STRUCTURE_1xax|  PDB=1xax  |  SCENE=  }}  


'''NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae'''
===NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae===




==Overview==
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The solution structure of the 154-residue conserved hypothetical protein HI0004 has been determined using multidimensional heteronuclear NMR spectroscopy. HI0004 has sequence homologs in many organisms ranging from bacteria to humans and is believed to be essential in Haemophilus influenzae, although an exact function has yet to be defined. It has a alpha-beta-alpha sandwich architecture consisting of a central four-stranded beta-sheet with the alpha2-helix packed against one side of the beta-sheet and four alpha-helices (alpha1, alpha3, alpha4, alpha5) on the other side. There is structural homology with the eukaryotic matrix metalloproteases (MMPs), but little sequence similarity except for a conserved region containing three histidines that appears in both the MMPs and throughout the HI0004 family of proteins. The solution structure of HI0004 is compared with the X-ray structure of an Aquifex aeolicus homolog, AQ_1354, which has 36% sequence identity over 148 residues. Despite this level of sequence homology, significant differences exist between the two structures. These differences are described along with possible functional implications of the structures.
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==About this Structure==
==About this Structure==
1XAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAX OCA].  
1XAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAX OCA].  


==Reference==
==Reference==
NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae, and comparison with the X-ray structure of an Aquifex aeolicus homolog., Yeh DC, Parsons LM, Parsons JF, Liu F, Eisenstein E, Orban J, Protein Sci. 2005 Feb;14(2):424-30. Epub 2005 Jan 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15632286 15632286]
NMR structure of HI0004, a putative essential gene product from Haemophilus influenzae, and comparison with the X-ray structure of an Aquifex aeolicus homolog., Yeh DC, Parsons LM, Parsons JF, Liu F, Eisenstein E, Orban J, Protein Sci. 2005 Feb;14(2):424-30. Epub 2005 Jan 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15632286 15632286]
NMR assignment of the hypothetical protein HI0004 from Haemophilus influenzae--a putative essential gene product., Cheon Yeh D, Parsons JF, Parsons LM, Liu F, Eisenstein E, Orban J, J Biomol NMR. 2004 May;29(1):101-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15017148 15017148]
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structure 2 function project]]
[[Category: Structure 2 function project]]
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