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'''Unreleased structure'''


The entry 22tg is ON HOLD
==Crystal Structure of MYST histone acetyltransferase KAT6A in complex with Compound 20==
 
<StructureSection load='22tg' size='340' side='right'caption='[[22tg]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: NarasimhaRao, K., Vijayshankar, N., SumalathaRani, T., Kalishankar, B., Chandregowda, V., Chandrasekar, A., Susanta, S., Raymond, A.N., David, C.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[22tg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=22TG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=22TG FirstGlance]. <br>
Description: Crystal Structure of MYST histone acetyltransferase KAT6A in complex with Compound 20
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1MDU:2,6-dimethoxy-~{N}-[4-(pyrazol-1-ylmethyl)-2,3-dihydrofuro[2,3-e][1,2]benzoxazol-8-yl]benzenesulfonamide'>A1MDU</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
[[Category: David, C.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=22tg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=22tg OCA], [https://pdbe.org/22tg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=22tg RCSB], [https://www.ebi.ac.uk/pdbsum/22tg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=22tg ProSAT]</span></td></tr>
[[Category: Narasimharao, K]]
</table>
[[Category: Kalishankar, B]]
== Function ==
[[Category: Chandregowda, V]]
[https://www.uniprot.org/uniprot/KAT8_HUMAN KAT8_HUMAN] Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex.<ref>PMID:12397079</ref> <ref>PMID:15923642</ref> <ref>PMID:20018852</ref>
[[Category: Susanta, S]]
== References ==
[[Category: Vijayshankar, N]]
<references/>
[[Category: Sumalatharani, T]]
__TOC__
[[Category: Raymond, A.N]]
</StructureSection>
[[Category: Chandrasekar, A]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chandrasekar A]]
[[Category: Chandregowda V]]
[[Category: David CM]]
[[Category: Kalishankar B]]
[[Category: NarasimhaRao K]]
[[Category: Raymond AN]]
[[Category: SumalathaRani T]]
[[Category: Susanta S]]
[[Category: Vijayshankar N]]
Retrieved from "https://proteopedia.org/22tg"