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'''Unreleased structure'''


The entry 9orm is ON HOLD  until 2027-05-22
==The structure of human Vacuolar Protein Sorting 34 catalytic domain bound to RD-I-137==
 
<StructureSection load='9orm' size='340' side='right'caption='[[9orm]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
Authors: Burtch, M., Abiodun, W., Litchfield, C., Cartwright, J., Doukov, T., Moody, J.D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9orm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ORM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ORM FirstGlance]. <br>
Description: The structure of human Vacuolar Protein Sorting 34 catalytic domain bound to RD-I-137
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CD6:ethyl+2-[(8S)-pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-benzothiazole-6-carboxylate'>A1CD6</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Cartwright, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9orm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9orm OCA], [https://pdbe.org/9orm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9orm RCSB], [https://www.ebi.ac.uk/pdbsum/9orm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9orm ProSAT]</span></td></tr>
[[Category: Doukov, T]]
</table>
[[Category: Abiodun, W]]
== Function ==
[[Category: Burtch, M]]
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
[[Category: Moody, J.D]]
== References ==
[[Category: Litchfield, C]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abiodun W]]
[[Category: Burtch M]]
[[Category: Cartwright J]]
[[Category: Doukov T]]
[[Category: Litchfield C]]
[[Category: Moody JD]]
Retrieved from "https://proteopedia.org/9orm"