9ov0: Difference between revisions
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==Structure of hTWIK2RM (K2P6.1RM) ion channel with lipid plug in DDM detergent== | |||
<StructureSection load='9ov0' size='340' side='right'caption='[[9ov0]], [[Resolution|resolution]] 3.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ov0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OV0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LBN:[(2~{R})-3-hexadecanoyloxy-2-[(~{Z})-octadec-9-enoyl]oxy-propyl]+2-(trimethylazaniumyl)ethyl+phosphate'>LBN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ov0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ov0 OCA], [https://pdbe.org/9ov0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ov0 RCSB], [https://www.ebi.ac.uk/pdbsum/9ov0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ov0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KCNK6_HUMAN KCNK6_HUMAN] K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system (PubMed:10887187, PubMed:28381826). Active in lysosomes where it regulates lysosome numbers and size (PubMed:28381826). In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux (By similarity).[UniProtKB:Q3TBV4]<ref>PMID:10887187</ref> <ref>PMID:28381826</ref> Does not display channel activity.<ref>PMID:10887187</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Minor DL]] | |||
[[Category: Mondal A]] | |||
Latest revision as of 04:53, 27 May 2026
Structure of hTWIK2RM (K2P6.1RM) ion channel with lipid plug in DDM detergent
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