9zke: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9zke is ~~ON HOLD until Paper Publication~~

==Structure of RY12 domain of rabbit RyR1 complexed with ARM210 and ATP==

~~Authors~~: ~~Kim~~, K., ~~Clarke~~, O.B.

== Structural highlights ==

<table><tr><td colspan='2'>[[9zke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZKE OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9ZKE FirstGlance].

~~Description~~: ~~Structure~~ of ~~RY12 domain~~ of ~~rabbit RyR1 complexed with ARM210~~ and ~~ATP~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.96Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=KVR:4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic+acid'>KVR</scene></td></tr>

[[Category: ~~Kim, K~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9zke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zke OCA], [https://pdbe.org/9zke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zke RCSB], [https://www.ebi.ac.uk/pdbsum/9zke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zke ProSAT]</td></tr>

[[Category: Clarke~~, O.B~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Oryctolagus cuniculus]]

[[Category: Clarke OB]]

[[Category: Kim K]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9zke is ON HOLD  until Paper Publication
+==Structure of RY12 domain of rabbit RyR1 complexed with ARM210 and ATP==
+<StructureSection load='9zke' size='340' side='right'caption='[[9zke]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
-Authors: Kim, K., Clarke, O.B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9zke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ZKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ZKE FirstGlance]. <br>
-Description: Structure of RY12 domain of rabbit RyR1 complexed with ARM210 and ATP
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.96&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=KVR:4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic+acid'>KVR</scene></td></tr>
-[[Category: Kim, K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9zke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9zke OCA], [https://pdbe.org/9zke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9zke RCSB], [https://www.ebi.ac.uk/pdbsum/9zke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9zke ProSAT]</span></td></tr>
-[[Category: Clarke, O.B]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Oryctolagus cuniculus]]
+[[Category: Clarke OB]]
+[[Category: Kim K]]