10nk: Difference between revisions
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The entry | ==Xenopus KCNQ1 Intermediate State (E1R/R2E) in complex with UCL2077== | ||
<StructureSection load='10nk' size='340' side='right'caption='[[10nk]], [[Resolution|resolution]] 3.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[10nk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10NK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10NK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.95Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C6W:1,1,1-triphenyl-~{N}-(pyridin-3-ylmethyl)methanamine'>A1C6W</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10nk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10nk OCA], [https://pdbe.org/10nk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10nk RCSB], [https://www.ebi.ac.uk/pdbsum/10nk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10nk ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Eldstrom J]] | |||
[[Category: Fedida D]] | |||
[[Category: Kyriakis E]] | |||
[[Category: Van Petegem F]] | |||
Latest revision as of 16:36, 8 September 2026
Xenopus KCNQ1 Intermediate State (E1R/R2E) in complex with UCL2077
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