11aa: Difference between revisions

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'''Unreleased structure'''


The entry 11aa is ON HOLD  until Paper Publication
==Yeast co-transcriptional pre-60S assembly intermediate Nop12 RNP==
<StructureSection load='11aa' size='340' side='right'caption='[[11aa]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[11aa]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11AA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11AA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11aa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11aa OCA], [https://pdbe.org/11aa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11aa RCSB], [https://www.ebi.ac.uk/pdbsum/11aa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11aa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NOP16_YEAST NOP16_YEAST] Involved in the biogenesis of the 60S ribosomal subunit.<ref>PMID:11583614</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Eukaryotic ribosomal large subunit (60 S ) assembly requires an internal transcribed spacer 2 (ITS2) to license both nucleolar and nuclear pre-60 S assembly intermediates. The underlying molecular mechanisms responsible for nucleation of pre-60 S assembly, quality control, and installation of ITS2 during co-transcriptional stages remain unknown. Here we report the earliest co-transcriptional assembly intermediates of the eukaryotic 60 S subunits. Together with biochemical assays, our data reveal the architecture of co-transcriptional pre-60 S assembly initiation and progression, as well as the molecular logic of an assembly checkpoint. This study highlights an evolutionary solution by which complex RNA folding processes can be parallelized and integrated via biological AND-gating.


Authors:  
Mechanism for the initiation of co-transcriptional pre-60 S assembly.,Piwowarczyk R, Klinge S bioRxiv [Preprint]. 2026 May 22:2026.05.22.727207. doi: , 10.64898/2026.05.22.727207. PMID:42239465<ref>PMID:42239465</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 11aa" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Klinge S]]
[[Category: Piwowarczyk R]]
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