1xjt: Difference between revisions

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[[Image:1xjt.gif|left|200px]]
{{Seed}}
[[Image:1xjt.png|left|200px]]


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{{STRUCTURE_1xjt|  PDB=1xjt  |  SCENE=  }}  
{{STRUCTURE_1xjt|  PDB=1xjt  |  SCENE=  }}  


'''Crystal structure of active form of P1 phage endolysin Lyz'''
===Crystal structure of active form of P1 phage endolysin Lyz===




==Overview==
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The P1 lysozyme Lyz is secreted to the periplasm of Escherichia coli and accumulates in an inactive membrane-tethered form. Genetic and biochemical experiments show that, when released from the bilayer, Lyz is activated by an intramolecular thiol-disulfide isomerization, which requires a cysteine in its N-terminal SAR (signal-arrest-release) domain. Crystal structures confirm the alternative disulfide linkages in the two forms of Lyz and reveal dramatic conformational differences in the catalytic domain. Thus, the exported P1 endolysin is kept inactive by three levels of control-topological, conformational, and covalent-until its release from the membrane is triggered by the P1 holin.
The line below this paragraph, {{ABSTRACT_PUBMED_15637279}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15637279}}


==About this Structure==
==About this Structure==
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[[Category: Sacchettini, J C.]]
[[Category: Sacchettini, J C.]]
[[Category: Open conformation]]
[[Category: Open conformation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:07:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:54:20 2008''
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