1xki: Difference between revisions

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[[Image:1xki.gif|left|200px]]
{{Seed}}
[[Image:1xki.png|left|200px]]


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{{STRUCTURE_1xki|  PDB=1xki  |  SCENE=  }}  
{{STRUCTURE_1xki|  PDB=1xki  |  SCENE=  }}  


'''Crystal structure of human tear lipocalin/von Ebners gland protein'''
===Crystal structure of human tear lipocalin/von Ebners gland protein===




==Overview==
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In contrast with earlier assumptions, which classified human tear lipocalin (Tlc) as an outlier member of the lipocalin protein family, the 1.8-A resolution crystal structure of the recombinant apoprotein confirms the typical eight-stranded antiparallel beta-barrel architecture with an alpha-helix attached to it. The fold of Tlc most closely resembles the bovine dander allergen Bos d 2, a well characterized prototypic lipocalin, but also reveals similarity with beta-lactoglobulin. However, compared with other lipocalin structures Tlc exhibits an extremely wide ligand pocket, whose entrance is formed by four partially disordered loops. The cavity deeply extends into the beta-barrel structure, where it ends in two distinct lobes. This unusual structural feature explains the known promiscuity of Tlc for various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampin and even to microbial siderophores. Notably, earlier findings of biological activity as a thiol protease inhibitor have no correspondence in the three-dimensional structure of Tlc, rather it appears that its proteolytic fragments could be responsible for this phenomenon. Hence, the present structural analysis sheds new light on the ligand binding activity of this functionally obscure but abundant human lipocalin.
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{{ABSTRACT_PUBMED_15489503}}


==About this Structure==
==About this Structure==
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Ligand binding protein]]
[[Category: Ligand binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:08:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:40:17 2008''

Revision as of 01:40, 29 July 2008

File:1xki.png

Template:STRUCTURE 1xki

Crystal structure of human tear lipocalin/von Ebners gland protein

Template:ABSTRACT PUBMED 15489503

About this Structure

1XKI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands., Breustedt DA, Korndorfer IP, Redl B, Skerra A, J Biol Chem. 2005 Jan 7;280(1):484-93. Epub 2004 Oct 15. PMID:15489503

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