1xm9: Difference between revisions

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[[Image:1xm9.gif|left|200px]]
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[[Image:1xm9.png|left|200px]]


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{{STRUCTURE_1xm9|  PDB=1xm9  |  SCENE=  }}  
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'''Structure of the armadillo repeat domain of plakophilin 1'''
===Structure of the armadillo repeat domain of plakophilin 1===




==Overview==
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The p120ctn subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins.
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{{ABSTRACT_PUBMED_15663951}}


==Disease==
==Disease==
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[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: Armadillo repeat]]
[[Category: Armadillo repeat]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:12:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:51:00 2008''

Revision as of 21:51, 27 July 2008

File:1xm9.png

Template:STRUCTURE 1xm9

Structure of the armadillo repeat domain of plakophilin 1

Template:ABSTRACT PUBMED 15663951

Disease

Known disease associated with this structure: Ectodermal dysplasia/skin fragility syndrome OMIM:[601975]

About this Structure

1XM9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the armadillo repeat domain of plakophilin 1., Choi HJ, Weis WI, J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:15663951

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