1xmo: Difference between revisions

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[[Image:1xmo.~~gif~~|left|200px]]

[[Image:1xmo.png|left|200px]]

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~~'''~~Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center~~'''~~

===Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center===

~~==Overview==~~

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The ~~natural modification of specific nucleosides in many tRNAs is essential during decoding of mRNA by the ribosome. For example~~, ~~tRNA(Lys)(UUU) requires the modification N6-threonylcarbamoyladenosine at position 37 (t(6)A37)~~, ~~adjacent and 3' to~~ the ~~anticodon,~~ to ~~bind AAA in~~ the ~~A site of the ribosomal 30S subunit. Moreover,~~ it ~~can only bind both AAA and AAG lysine codons when doubly modified with t(6)A37 and either 5-methylaminomethyluridine or 2-thiouridine~~ at ~~the wobble position (mnm(5)U34 or s(2)U34)~~. ~~Here we report crystal structures of modified tRNA anticodon stem-loops bound to the 30S ribosomal subunit with lysine codons in the A site~~. ~~These structures allow~~ the ~~rationalization of how modifications in the anticodon loop enable decoding of both lysine codons AAA and AAG~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15558052}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15558052 is the PubMed ID number.

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==About this Structure==

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[[Category: Ribosome]]

[[Category: Trna modification]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 15~~:13:57 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:31:35 2008''

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-[[Image:1xmo.gif|left|200px]]
+{{Seed}}
+[[Image:1xmo.png|left|200px]]
 <!--
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 {{STRUCTURE_1xmo|  PDB=1xmo  |  SCENE=  }}
-'''Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center'''
+===Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center===
-==Overview==
+<!--
-The natural modification of specific nucleosides in many tRNAs is essential during decoding of mRNA by the ribosome. For example, tRNA(Lys)(UUU) requires the modification N6-threonylcarbamoyladenosine at position 37 (t(6)A37), adjacent and 3' to the anticodon, to bind AAA in the A site of the ribosomal 30S subunit. Moreover, it can only bind both AAA and AAG lysine codons when doubly modified with t(6)A37 and either 5-methylaminomethyluridine or 2-thiouridine at the wobble position (mnm(5)U34 or s(2)U34). Here we report crystal structures of modified tRNA anticodon stem-loops bound to the 30S ribosomal subunit with lysine codons in the A site. These structures allow the rationalization of how modifications in the anticodon loop enable decoding of both lysine codons AAA and AAG.
+The line below this paragraph, {{ABSTRACT_PUBMED_15558052}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15558052 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15558052}}
 ==About this Structure==
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 [[Category: Ribosome]]
 [[Category: Trna modification]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:13:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:31:35 2008''