9qru: Difference between revisions
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==Cryo-EM structure of the MMM ubiquitin ligase complex with nanobody 270 (Composite map)== | |||
<StructureSection load='9qru' size='340' side='right'caption='[[9qru]], [[Resolution|resolution]] 3.03Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9qru]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QRU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.03Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JAX:(1~{S},2~{S},4~{S},5~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-16-methoxy-5,7,9,13-tetramethyl-spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2-oxane]'>A1JAX</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qru OCA], [https://pdbe.org/9qru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qru RCSB], [https://www.ebi.ac.uk/pdbsum/9qru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qru ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MGRN1_HUMAN MGRN1_HUMAN] E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H (PubMed:17229889, PubMed:19703557). Plays a role in the regulation of endosome-to-lysosome trafficking (PubMed:17229889). Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production (PubMed:19737927). Does not inhibit ADRB2-signaling (PubMed:19737927). Does not promote MC1R ubiquitination (PubMed:19737927). Acts also as a negative regulator of hedgehog signaling (By similarity).[UniProtKB:Q9D074]<ref>PMID:17229889</ref> <ref>PMID:19703557</ref> <ref>PMID:19737927</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Lama glama]] | |||
[[Category: Large Structures]] | |||
[[Category: Bazan F]] | |||
[[Category: Carrique L]] | |||
[[Category: Chalk R]] | |||
[[Category: Gao L]] | |||
[[Category: Hedger G]] | |||
[[Category: Kong JH]] | |||
[[Category: Lartey D]] | |||
[[Category: Latorraca NR]] | |||
[[Category: Marqusee S]] | |||
[[Category: Milenkovic L]] | |||
[[Category: Nocka LM]] | |||
[[Category: Parashara P]] | |||
[[Category: Pardon E]] | |||
[[Category: Pusapati GV]] | |||
[[Category: Rohatgi R]] | |||
[[Category: Rouse SL]] | |||
[[Category: Sarkar P]] | |||
[[Category: Siebold C]] | |||
[[Category: Steyaert J]] | |||
[[Category: Williams C]] | |||
Latest revision as of 04:55, 27 May 2026
Cryo-EM structure of the MMM ubiquitin ligase complex with nanobody 270 (Composite map)
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