1xod: Difference between revisions

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{{Seed}}
[[Image:1xod.gif|left|200px]]
[[Image:1xod.gif|left|200px]]


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{{STRUCTURE_1xod|  PDB=1xod  |  SCENE=  }}  
{{STRUCTURE_1xod|  PDB=1xod  |  SCENE=  }}  


'''Crystal structure of X. tropicalis Spred1 EVH-1 domain'''
===Crystal structure of X. tropicalis Spred1 EVH-1 domain===




==Overview==
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The recently described Spred protein family has been implicated in the modulation of receptor tyrosine kinase signalling. We report the crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution. This structure confirms that the Spred EVH1 adopts the pleckstrin-homology fold, with a similar secondary structure to Enabled. A translation of one of the peptide-binding groove beta-strands narrows this groove, whilst one end of the groove shows structural flexibility. We propose that Spred1 will bind peptides that are less proline-rich than other EVH1 domains, with conformational changes indicating an induced fit.
The line below this paragraph, {{ABSTRACT_PUBMED_15710406}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15710406 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15710406}}


==About this Structure==
==About this Structure==
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[[Category: Spred]]
[[Category: Spred]]
[[Category: Sprouty]]
[[Category: Sprouty]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:17:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:56:06 2008''

Revision as of 14:56, 28 July 2008

File:1xod.gif

Template:STRUCTURE 1xod

Crystal structure of X. tropicalis Spred1 EVH-1 domain

Template:ABSTRACT PUBMED 15710406

About this Structure

1XOD is a Single protein structure of sequence from Xenopus tropicalis. Full crystallographic information is available from OCA.

Reference

1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family., Harmer NJ, Sivak JM, Amaya E, Blundell TL, FEBS Lett. 2005 Feb 14;579(5):1161-6. PMID:15710406

Page seeded by OCA on Mon Jul 28 17:56:06 2008

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