1xp8: Difference between revisions

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[[Image:1xp8.jpg|left|200px]]
{{Seed}}
[[Image:1xp8.png|left|200px]]


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{{STRUCTURE_1xp8|  PDB=1xp8  |  SCENE=  }}  
{{STRUCTURE_1xp8|  PDB=1xp8  |  SCENE=  }}  


'''"Deinococcus radiodurans RecA in complex with ATP-gamma-S"'''
==="Deinococcus radiodurans RecA in complex with ATP-gamma-S"===




==Overview==
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The resistance of Deinococcus radiodurans (Dr) to extreme doses of ionizing radiation depends on its highly efficient capacity to repair dsDNA breaks. Dr RecA, the key protein in the repair of dsDNA breaks by homologous recombination, promotes DNA strand-exchange by an unprecedented inverse pathway, in which the presynaptic filament is formed on dsDNA instead of ssDNA. In order to gain insight into the remarkable repair capacity of Dr and the novel mechanistic features of its RecA protein, we have determined its X-ray crystal structure in complex with ATPgammaS at 2.5A resolution. Like RecA from Escherichia coli, Dr RecA crystallizes as a helical filament that is closely related to its biologically relevant form, but with a more compressed pitch of 67 A. Although the overall fold of Dr RecA is similar to E.coli RecA, there is a large reorientation of the C-terminal domain, which in E.coli RecA has a site for binding dsDNA. Compared to E.coli RecA, the inner surface along the central axis of the Dr RecA filament has an increased positive electrostatic potential. Unique amino acid residues in Dr RecA cluster around a flexible beta-hairpin that has also been implicated in DNA binding.
The line below this paragraph, {{ABSTRACT_PUBMED_15544805}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15544805 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15544805}}


==About this Structure==
==About this Structure==
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[[Category: Radioresistance]]
[[Category: Radioresistance]]
[[Category: Recombination]]
[[Category: Recombination]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:19:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:40:51 2008''

Revision as of 01:40, 28 July 2008

File:1xp8.png

Template:STRUCTURE 1xp8

"Deinococcus radiodurans RecA in complex with ATP-gamma-S"

Template:ABSTRACT PUBMED 15544805

About this Structure

1XP8 is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Crystal structure of RecA from Deinococcus radiodurans: insights into the structural basis of extreme radioresistance., Rajan R, Bell CE, J Mol Biol. 2004 Dec 3;344(4):951-63. PMID:15544805

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