1xq8: Difference between revisions

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[[Image:1xq8.gif|left|200px]]
{{Seed}}
[[Image:1xq8.png|left|200px]]


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{{STRUCTURE_1xq8|  PDB=1xq8  |  SCENE=  }}  
{{STRUCTURE_1xq8|  PDB=1xq8  |  SCENE=  }}  


'''Human micelle-bound alpha-synuclein'''
===Human micelle-bound alpha-synuclein===




==Overview==
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Misfolding of the protein alpha-synuclein (aS), which associates with presynaptic vesicles, has been implicated in the molecular chain of events leading to Parkinson's disease. Here, the structure and dynamics of micelle-bound aS are reported. Val3-Val37 and Lys45-Thr92 form curved alpha-helices, connected by a well ordered, extended linker in an unexpected anti-parallel arrangement, followed by another short extended region (Gly93-Lys97), overlapping the recently identified chaperone-mediated autophagy recognition motif and a highly mobile tail (Asp98-Ala140). Helix curvature is significantly less than predicted based on the native micelle shape, indicating a deformation of the micelle by aS. Structural and dynamic parameters show a reduced helical content for Ala30-Val37. A dynamic variation in interhelical distance on the microsecond timescale is complemented by enhanced sub-nanosecond timescale dynamics, particularly in the remarkably glycine-rich segments of the helices. These unusually rich dynamics may serve to mitigate the effect of aS binding on membrane fluidity. The well ordered conformation of the helix-helix connector indicates a defined interaction with lipidic surfaces, suggesting that, when bound to larger diameter synaptic vesicles, it can act as a switch between this structure and a previously proposed uninterrupted helix.
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(as it appears on PubMed at http://www.pubmed.gov), where 15615727 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15615727}}


==About this Structure==
==About this Structure==
1XQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQ8 OCA].  
1XQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQ8 OCA].  


==Reference==
==Reference==
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[[Category: Ulmer, T S.]]
[[Category: Ulmer, T S.]]
[[Category: Micelle-bound helix]]
[[Category: Micelle-bound helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:21:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:45:05 2008''

Revision as of 01:45, 28 July 2008

File:1xq8.png

Template:STRUCTURE 1xq8

Human micelle-bound alpha-synuclein

Template:ABSTRACT PUBMED 15615727

About this Structure

1XQ8 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and dynamics of micelle-bound human alpha-synuclein., Ulmer TS, Bax A, Cole NB, Nussbaum RL, J Biol Chem. 2005 Mar 11;280(10):9595-603. Epub 2004 Dec 22. PMID:15615727

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