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[[Image:1xs0.jpg|left|200px]]
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{{STRUCTURE_1xs0|  PDB=1xs0  |  SCENE=  }}  
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'''Structure of the E. coli Ivy protein'''
===Structure of the E. coli Ivy protein===




==Overview==
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The complete nucleotide sequences of over 37 microbial and three eukaryote genomes are already publicly available, and more sequencing is in progress. Despite this accumulation of data, newly sequenced microbial genomes continue to reveal up to 50% of functionally uncharacterized "anonymous" genes. A majority of these anonymous proteins have homologues in other organisms, whereas the rest exhibit no clear similarity to any other sequence in the data bases. This set of unique, apparently species-specific, sequences are referred to as ORFans. The biochemical and structural analysis of ORFan gene products is of both evolutionary and functional interest. Here we report the cloning and expression of Escherichia coli ORFan ykfE gene and the functional characterization of the encoded protein. Under physiological conditions, the protein is a homodimer with a strong affinity for C-type lysozyme, as revealed by co-purification and co-crystallization. Activity measurements and fluorescence studies demonstrated that the YkfE gene product is a potent C-type lysozyme inhibitor (K(i) approximately 1 nm). To denote this newly assigned function, ykfE has now been registered under the new gene name Ivy (inhibitor of vertebrate lysozyme) at the E. coli genetic stock center.
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{{ABSTRACT_PUBMED_17405861}}


==About this Structure==
==About this Structure==
1XS0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XS0 OCA].  
1XS0 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k12 Escherichia coli k12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XS0 OCA].  


==Reference==
==Reference==
Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme., Monchois V, Abergel C, Sturgis J, Jeudy S, Claverie JM, J Biol Chem. 2001 May 25;276(21):18437-41. Epub 2001 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11278658 11278658]
<ref group="xtra">PMID:17405861</ref><ref group="xtra">PMID:11278658</ref><ref group="xtra">PMID:11092949</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli k12]]
[[Category: Single protein]]
[[Category: Abergel, C.]]
[[Category: Abergel, C.]]
[[Category: Byrn, D.]]
[[Category: Byrn, D.]]
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[[Category: Alpha beta fold]]
[[Category: Alpha beta fold]]
[[Category: Dimer]]
[[Category: Dimer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:26:16 2008''
[[Category: Hydrolase inhibitor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 09:10:12 2009''

Revision as of 07:10, 21 January 2009

File:1xs0.png

Template:STRUCTURE 1xs0

Structure of the E. coli Ivy protein

Template:ABSTRACT PUBMED 17405861

About this Structure

1XS0 is a 3 chains structure of sequences from Escherichia coli k12. Full crystallographic information is available from OCA.

Reference

  1. Abergel C, Monchois V, Byrne D, Chenivesse S, Lembo F, Lazzaroni JC, Claverie JM. Structure and evolution of the Ivy protein family, unexpected lysozyme inhibitors in Gram-negative bacteria. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6394-9. Epub 2007 Apr 3. PMID:17405861
  2. Monchois V, Abergel C, Sturgis J, Jeudy S, Claverie JM. Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme. J Biol Chem. 2001 May 25;276(21):18437-41. Epub 2001 Feb 23. PMID:11278658 doi:10.1074/jbc.M010297200
  3. Abergel C, Monchois V, Chenivesse S, Jeudy S, Claverie JM. Crystallization and preliminary crystallographic study of b0220, an 'ORFan' protein of unknown function from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1694-5. PMID:11092949

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