1xs7: Difference between revisions

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[[Image:1xs7.gif|left|200px]]
{{Seed}}
[[Image:1xs7.png|left|200px]]


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{{STRUCTURE_1xs7|  PDB=1xs7  |  SCENE=  }}  
{{STRUCTURE_1xs7|  PDB=1xs7  |  SCENE=  }}  


'''Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).'''
===Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).===




==Overview==
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A series of novel macrocyclic amide-urethanes was designed and synthesized based upon the X-ray crystal structure of our lead inhibitor (1, OM99-2 with eight residues) bound to memapsin 2. Ring size and substituent effects have been investigated. Cycloamide-urethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against human brain memapsin 2 (beta-secretase).
The line below this paragraph, {{ABSTRACT_PUBMED_15582402}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15582402}}


==About this Structure==
==About this Structure==
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[[Category: Drug design]]
[[Category: Drug design]]
[[Category: Memapsin2]]
[[Category: Memapsin2]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:26:46 2008''
 
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