11ya: Difference between revisions

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'''Unreleased structure'''


The entry 11ya is ON HOLD  until Paper Publication
==Staphylococcus aureus MurJ R176A mutant==
<StructureSection load='11ya' size='340' side='right'caption='[[11ya]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[11ya]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11YA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11YA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11ya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11ya OCA], [https://pdbe.org/11ya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11ya RCSB], [https://www.ebi.ac.uk/pdbsum/11ya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11ya ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q2FXH6_STAA8 Q2FXH6_STAA8]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Peptidoglycan biogenesis requires membrane flippases to translocate lipid-linked precursors across the cytoplasmic membrane for processing. This essential step is mediated by MurJ, the lipid II flippase conserved across all peptidoglycan-producing bacteria. While MurJ from diderm bacteria has been structurally resolved in multiple conformational states, its monoderm homolog remains uncharacterized. Monoderm MurJ homologs exhibit substantial sequence divergence yet retain the same lipid II flipping function and are promising antibiotic targets. Here we report structures of Staphylococcus aureus MurJ (SaMurJ) captured in both outward- and inward-facing conformations. These structures show that SaMurJ adopts the conserved MOP family fold and undergoes conformational transitions consistent with an alternating-access mechanism. Our findings reveal conserved and divergent features of MurJ between diderm and monoderm bacteria that are critical for lipid II flipping and provide a structural framework for probing substrate recognition and specific inhibition.


Authors:  
Structures of the lipid II flippase from the monoderm pathogen Staphylococcus aureus.,Li YE, Baron GF, Clemons WM Jr J Biol Chem. 2026 Sep 5:113516. doi: 10.1016/j.jbc.2026.113516. PMID:42700959<ref>PMID:42700959</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 11ya" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
[[Category: Clemons WM]]
[[Category: Li YE]]
Retrieved from "https://proteopedia.org/11ya"