24vj: Difference between revisions
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==Cryo-EM structure of the human KCNQ2/KCNQ3 heterotetramer (3:1 stoichiometry) with CLM142 (M2223 CLM142, without symmetry expansion)== | |||
<StructureSection load='24vj' size='340' side='right'caption='[[24vj]], [[Resolution|resolution]] 3.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[24vj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=24VJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=24VJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.07Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9PE:(1R)-2-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(HEPTANOYLOXY)METHYL]ETHYL+OCTADECANOATE'>9PE</scene>, <scene name='pdbligand=A1E7E:~{N}-(7-cyclopropyl-1-prop-2-ynyl-indazol-3-yl)-4-fluoranyl-benzamide'>A1E7E</scene>, <scene name='pdbligand=YJ0:(2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl+4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside'>YJ0</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=24vj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=24vj OCA], [https://pdbe.org/24vj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=24vj RCSB], [https://www.ebi.ac.uk/pdbsum/24vj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=24vj ProSAT]</span></td></tr> | ||
[[Category: Shen | </table> | ||
[[Category: Wang | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/KCNQ3_HUMAN KCNQ3_HUMAN] Benign familial infantile epilepsy;Benign familial neonatal seizures;Juvenile myoclonic epilepsy. The disease is caused by mutations affecting the gene represented in this entry. Defects in KCNQ3 may be involved in epileptic disorders. These are characterized by paroxysmal transient disturbances of the electrical activity of the brain that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances, or perturbation of the autonomic nervous system.<ref>PMID:22612257</ref> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KCNQ3_HUMAN KCNQ3_HUMAN] Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aequorea victoria]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Qu YN]] | |||
[[Category: Shen HZ]] | |||
[[Category: Wang YF]] | |||
[[Category: Yang H]] | |||
Latest revision as of 04:50, 13 August 2026
Cryo-EM structure of the human KCNQ2/KCNQ3 heterotetramer (3:1 stoichiometry) with CLM142 (M2223 CLM142, without symmetry expansion)
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