10jv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 10jv is ~~ON HOLD until Paper Publication~~

==Crystal structure of human CHI3L1 in complex with the CHI-DEL small molecule==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[10jv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10JV OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=10JV FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C9M:(2~{S},4~{S})-4-[(4-fluoranylnaphthalen-1-yl)sulfonylamino]-~{N}-methyl-1-[(2-methyl-1,3-benzoxazol-6-yl)carbonyl]pyrrolidine-2-carboxamide'>A1C9M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=10jv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10jv OCA], [https://pdbe.org/10jv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10jv RCSB], [https://www.ebi.ac.uk/pdbsum/10jv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10jv ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.

== Function ==

[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Gabr M]]

[[Category: Teplova M]]

[[Category: Upadhyay S]]

[[Category: Zhang L]]

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-'''Unreleased structure'''
-The entry 10jv is ON HOLD  until Paper Publication
+==Crystal structure of human CHI3L1 in complex with the CHI-DEL small molecule==
+<StructureSection load='10jv' size='340' side='right'caption='[[10jv]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[10jv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10JV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10JV FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1C9M:(2~{S},4~{S})-4-[(4-fluoranylnaphthalen-1-yl)sulfonylamino]-~{N}-methyl-1-[(2-methyl-1,3-benzoxazol-6-yl)carbonyl]pyrrolidine-2-carboxamide'>A1C9M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10jv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10jv OCA], [https://pdbe.org/10jv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10jv RCSB], [https://www.ebi.ac.uk/pdbsum/10jv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10jv ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
+== Function ==
+[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gabr M]]
+[[Category: Teplova M]]
+[[Category: Upadhyay S]]
+[[Category: Zhang L]]