29ob: Difference between revisions

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'''Unreleased structure'''


The entry 29ob is ON HOLD  until Paper Publication
==Crystal structure of RORg LBD in complex with DHEA==
 
<StructureSection load='29ob' size='340' side='right'caption='[[29ob]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
Authors: Morozov, V., Lopez-Garcia, U., Merk, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[29ob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=29OB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=29OB FirstGlance]. <br>
Description: Crystal structure of RORg LBD in complex with DHEA
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AND:3-BETA-HYDROXY-5-ANDROSTEN-17-ONE'>AND</scene></td></tr>
[[Category: Morozov, V]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=29ob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=29ob OCA], [https://pdbe.org/29ob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=29ob RCSB], [https://www.ebi.ac.uk/pdbsum/29ob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=29ob ProSAT]</span></td></tr>
[[Category: Merk, D]]
</table>
[[Category: Lopez-Garcia, U]]
== Function ==
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lopez-Garcia U]]
[[Category: Merk D]]
[[Category: Morozov V]]
Retrieved from "https://proteopedia.org/29ob"