9t8c: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9t8c is ~~ON HOLD~~

==Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9t8c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T8C OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9T8C FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RU:3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea'>7RU</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9t8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t8c OCA], [https://pdbe.org/9t8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t8c RCSB], [https://www.ebi.ac.uk/pdbsum/9t8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t8c ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/A0A2R9AV93_PANPA A0A2R9AV93_PANPA] Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions. Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior. Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels. Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders. Promotes cell proliferation through MAP kinase signaling. Also involved in autophagy regulation: receptor activation stimulates AMPK, which phosphorylates RPTOR and enhances its interaction with MTOR, thereby inhibiting MTORC1 signaling and its downstream target RPS6KB1. This leads to activation of ULK1 and initiation of the autophagy cascade. Forms heterotetramers with DRD1 to potentiate beta-arrestin recruitment and mediate locomotor activity.[ARBA:ARBA00094249]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Keseru GM]]

[[Category: Kiss DJ]]

[[Category: Shalev-Benami M]]

[[Category: Yardeni EH]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9t8c is ON HOLD
+==Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go==
+<StructureSection load='9t8c' size='340' side='right'caption='[[9t8c]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9t8c]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T8C FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RU:3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea'>7RU</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t8c OCA], [https://pdbe.org/9t8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t8c RCSB], [https://www.ebi.ac.uk/pdbsum/9t8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t8c ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A2R9AV93_PANPA A0A2R9AV93_PANPA] Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions. Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior. Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels. Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders. Promotes cell proliferation through MAP kinase signaling. Also involved in autophagy regulation: receptor activation stimulates AMPK, which phosphorylates RPTOR and enhances its interaction with MTOR, thereby inhibiting MTORC1 signaling and its downstream target RPS6KB1. This leads to activation of ULK1 and initiation of the autophagy cascade. Forms heterotetramers with DRD1 to potentiate beta-arrestin recruitment and mediate locomotor activity.[ARBA:ARBA00094249]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Keseru GM]]
+[[Category: Kiss DJ]]
+[[Category: Shalev-Benami M]]
+[[Category: Yardeni EH]]