1xvo: Difference between revisions

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[[Image:1xvo.gif|left|200px]]
{{Seed}}
[[Image:1xvo.png|left|200px]]


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{{STRUCTURE_1xvo|  PDB=1xvo  |  SCENE=  }}  
{{STRUCTURE_1xvo|  PDB=1xvo  |  SCENE=  }}  


'''Trypsin from Fusarium oxysporum at pH 6'''
===Trypsin from Fusarium oxysporum at pH 6===




==Overview==
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The analysis of anisotropic atomic displacement parameters for the direct extraction of functionally relevant motion from X-ray crystal structures of Fusarium oxysporum trypsin is presented. Several atomic resolution structures complexed with inhibitors or substrates and determined at different pH values and temperatures were investigated. The analysis revealed a breathing-like molecular motion conserved across trypsin structures from two organisms and three different crystal forms. Directional motion was observed suggesting a change of the width of the substrate-binding cleft and a change in the length of the specificity pocket. The differences in direction of motion across the structures are dependent on the mode of substrate or inhibitor binding and the chemical environment around the active-site residues. Together with the occurrence of multiple-residue conformers, they reflect spatial rearrangement throughout the deacylation pathway.
The line below this paragraph, {{ABSTRACT_PUBMED_16041079}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16041079}}


==About this Structure==
==About this Structure==
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[[Category: Atomic resolution]]
[[Category: Atomic resolution]]
[[Category: Trypsin]]
[[Category: Trypsin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:33:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:17:20 2008''

Revision as of 10:17, 29 July 2008

File:1xvo.png

Template:STRUCTURE 1xvo

Trypsin from Fusarium oxysporum at pH 6

Template:ABSTRACT PUBMED 16041079

About this Structure

1XVO is a Single protein structure of sequence from Fusarium oxysporum. Full crystallographic information is available from OCA.

Reference

Extraction of functional motion in trypsin crystal structures., Schmidt A, Lamzin VS, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1132-9. Epub 2005, Jul 20. PMID:16041079

Page seeded by OCA on Tue Jul 29 13:17:20 2008

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