13bv: Difference between revisions
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==Cryo-EM structure of human PI3KC3-C1 complex== | |||
<StructureSection load='13bv' size='340' side='right'caption='[[13bv]], [[Resolution|resolution]] 3.77Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[13bv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=13BV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=13BV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.77Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=13bv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=13bv OCA], [https://pdbe.org/13bv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=13bv RCSB], [https://www.ebi.ac.uk/pdbsum/13bv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=13bv ProSAT]</span></td></tr> | ||
[[Category: Chen | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen M]] | |||
[[Category: Hurley JH]] | |||
Latest revision as of 03:36, 14 May 2026
Cryo-EM structure of human PI3KC3-C1 complex
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