2b5i: Difference between revisions

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[[Image:2b5i.gif|left|200px]]<br />

[[Image:2b5i.gif|left|200px]]<br /><applet load="2b5i" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2b5i" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2b5i, resolution 2.30Å" />

'''cytokine receptor complex'''<br />

==Overview==

Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a, quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta, (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of, the quaternary ectodomain complex as visualized at a resolution of 2.3, angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary, binding site for presentation to IL-2Rbeta. gammac is then recruited to, the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent, with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac, provides a rationale for loss-of-function mutations found in patients with, X-linked severe combined immunodeficiency diseases (X-SCID). This complex, structure provides a framework for other gammac-dependent, cytokine-receptor interactions and for the engineering of improved IL-2, therapeutics.

Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac provides a rationale for loss-of-function mutations found in patients with X-linked severe combined immunodeficiency diseases (X-SCID). This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics.

==Disease==

Known diseases associated with this structure: Combined immunodeficiency, X-linked, moderate OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308380 308380]], Diabetes mellitus, insulin-dependent, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]], Severe combined immunodeficiency, X-linked OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308380 308380]]

Known diseases associated with this structure: Combined immunodeficiency, X-linked, moderate OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308380 308380]], Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]], Severe combined immunodeficiency, X-linked OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308380 308380]]

==About this Structure==

2B5I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2B5I OCA].

2B5I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B5I OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Garcia, K.C.]]

[[Category: Garcia, K C.]]

[[Category: Rickert, M.]]

[[Category: Wang, X.]]

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[[Category: four-helix bundle]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 20~~:59:~~01 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:34:23 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2b5i.gif|left|200px]]<br />
+[[Image:2b5i.gif|left|200px]]<br /><applet load="2b5i" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2b5i" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2b5i, resolution 2.30&Aring;" />
 '''cytokine receptor complex'''<br />
 ==Overview==
-Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a, quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta, (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of, the quaternary ectodomain complex as visualized at a resolution of 2.3, angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary, binding site for presentation to IL-2Rbeta. gammac is then recruited to, the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent, with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac, provides a rationale for loss-of-function mutations found in patients with, X-linked severe combined immunodeficiency diseases (X-SCID). This complex, structure provides a framework for other gammac-dependent, cytokine-receptor interactions and for the engineering of improved IL-2, therapeutics.
+Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gc) receptors. In the structure of the quaternary ectodomain complex as visualized at a resolution of 2.3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex. Consistent with its role as a shared receptor for IL-4, IL-7, IL-9, IL-15, and IL-21, gammac forms degenerate contacts with IL-2. The structure of gammac provides a rationale for loss-of-function mutations found in patients with X-linked severe combined immunodeficiency diseases (X-SCID). This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics.
 ==Disease==
-Known diseases associated with this structure: Combined immunodeficiency, X-linked, moderate OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308380 308380]], Diabetes mellitus, insulin-dependent, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]], Severe combined immunodeficiency, X-linked OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308380 308380]]
+Known diseases associated with this structure: Combined immunodeficiency, X-linked, moderate OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308380 308380]], Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]], Severe combined immunodeficiency, X-linked OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308380 308380]]
 ==About this Structure==
-B5I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2B5I OCA].
+B5I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B5I OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Garcia, K.C.]]
+[[Category: Garcia, K C.]]
 [[Category: Rickert, M.]]
 [[Category: Wang, X.]]
@@ Line 24: / Line 23: @@
 [[Category: four-helix bundle]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:59:01 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:34:23 2008''