1y02: Difference between revisions

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[[Image:1y02.gif|left|200px]]
{{Seed}}
[[Image:1y02.png|left|200px]]


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{{STRUCTURE_1y02|  PDB=1y02  |  SCENE=  }}  
{{STRUCTURE_1y02|  PDB=1y02  |  SCENE=  }}  


'''Crystal Structure of a FYVE-type domain from caspase regulator CARP2'''
===Crystal Structure of a FYVE-type domain from caspase regulator CARP2===




==Overview==
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The caspase-associated ring proteins (CARP1 and CARP2) are distinguished from other caspase regulators by the presence of a FYVE-type zinc finger domain. FYVE-type domains are divided into two known classes: FYVE domains that specifically bind to phosphatidylinositol 3-phosphate in lipid bilayers and FYVE-related domains of undetermined function. Here, we report the crystal structure of the N-terminal region of CARP2 (44-139) including the FYVE-type domain and its associated helical bundle at 1.7 A resolution. The structure reveals a cramped phosphoinositide binding pocket and a blunted membrane insertion loop. These structural features indicate that the domain is not optimized to bind to phosphoinositides or insert into lipid bilayers. The CARP2 FYVE-like domain thus defines a third subfamily of FYVE-type domains that are functionally and structurally distinct. Structural analyses provide insights into the possible function of this unique subfamily of FYVE-type domains.
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{{ABSTRACT_PUBMED_15576038}}


==About this Structure==
==About this Structure==
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[[Category: Phosphoinositide binding]]
[[Category: Phosphoinositide binding]]
[[Category: Zinc-binding module]]
[[Category: Zinc-binding module]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:43:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:32:56 2008''

Revision as of 14:33, 27 July 2008

File:1y02.png

Template:STRUCTURE 1y02

Crystal Structure of a FYVE-type domain from caspase regulator CARP2

Template:ABSTRACT PUBMED 15576038

About this Structure

1Y02 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2., Tibbetts MD, Shiozaki EN, Gu L, McDonald ER 3rd, El-Deiry WS, Shi Y, Structure. 2004 Dec;12(12):2257-63. PMID:15576038

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