9s0r: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Cryo-EM structure of human NHE6 in C1 symmetry== | |||
<StructureSection load='9s0r' size='340' side='right'caption='[[9s0r]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9s0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S0R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s0r OCA], [https://pdbe.org/9s0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s0r RCSB], [https://www.ebi.ac.uk/pdbsum/9s0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s0r ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/SL9A6_HUMAN SL9A6_HUMAN] Christianson syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease may be caused by variants affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/SL9A6_HUMAN SL9A6_HUMAN] Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:28635961, PubMed:31676550, PubMed:32277048). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracellular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity).[UniProtKB:A1L3P4]<ref>PMID:15522866</ref> <ref>PMID:20130086</ref> <ref>PMID:28635961</ref> <ref>PMID:31676550</ref> <ref>PMID:32277048</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Autzen HE]] | ||
[[Category: | [[Category: Brauer CM]] | ||
[[Category: | [[Category: Faergeman NJ]] | ||
[[Category: Feilen LP]] | |||
[[Category: Ginsthofer M]] | |||
[[Category: Havelund JF]] | |||
[[Category: Kragelund BB]] | |||
[[Category: Lalic MR]] | |||
[[Category: Ma L]] | |||
[[Category: Morrow EM]] | |||
[[Category: Ostendorf J]] | |||
[[Category: Pedersen SF]] | |||
[[Category: Sach L]] | |||
[[Category: Tranchant EE]] | |||
Latest revision as of 17:57, 25 September 2026
Cryo-EM structure of human NHE6 in C1 symmetry
| ||||||||||||
