1y12: Difference between revisions

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[[Image:1y12.~~gif~~|left|200px]]

[[Image:1y12.png|left|200px]]

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~~'''~~Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa~~'''~~

===Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa===

~~==Overview==~~

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~~Bacterial pathogens frequently use protein secretion~~ to ~~mediate interactions with their hosts. Here we found that a virulence locus~~ (~~HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus~~. ~~The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter~~. ~~Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF~~) ~~patients and Hcp1-specific antibodies in their sera. Thus~~, ~~HSI-I likely contributes to~~ the ~~pathogenesis of P~~. ~~aeruginosa in CF patients. HSI~~-I-~~related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16763151}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16763151 is the PubMed ID number.

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==About this Structure==

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[[Category: Psi]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 15~~:45:21 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:45:35 2008''

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-[[Image:1y12.gif|left|200px]]
+{{Seed}}
+[[Image:1y12.png|left|200px]]
 <!--
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 {{STRUCTURE_1y12|  PDB=1y12  |  SCENE=  }}
-'''Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa'''
+===Structure of a hemolysin-coregulated protein from Pseudomonas aeruginosa===
-==Overview==
+<!--
-Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.
+The line below this paragraph, {{ABSTRACT_PUBMED_16763151}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16763151 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16763151}}
 ==About this Structure==
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 [[Category: Psi]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:45:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:45:35 2008''