1y2q: Difference between revisions

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[[Image:1y2q.gif|left|200px]]
{{Seed}}
[[Image:1y2q.png|left|200px]]


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{{STRUCTURE_1y2q|  PDB=1y2q  |  SCENE=  }}  
{{STRUCTURE_1y2q|  PDB=1y2q  |  SCENE=  }}  


'''Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi'''
===Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi===




==Overview==
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We report the crystal structure of an archaea-specific editing domain of threonyl-tRNA synthetase that reveals a marked structural similarity to D-amino acid deacylases found in eubacteria and eukaryotes. The domain can bind D-amino acids despite a low sequence identity to other D-amino acid deacylases. These results together indicate the presence of these deacylases in all three kingdoms of life. This underlines an important role they may have played in enforcing homochirality during translation.
The line below this paragraph, {{ABSTRACT_PUBMED_15908961}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15908961}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
A D-amino acid editing module coupled to the translational apparatus in archaea., Dwivedi S, Kruparani SP, Sankaranarayanan R, Nat Struct Mol Biol. 2005 Jun;12(6):556-7. Epub 2005 May 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15908961 15908961]
A D-amino acid editing module coupled to the translational apparatus in archaea., Dwivedi S, Kruparani SP, Sankaranarayanan R, Nat Struct Mol Biol. 2005 Jun;12(6):556-7. Epub 2005 May 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15908961 15908961]
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic investigations of a unique editing domain from archaebacteria., Dwivedi S, Kruparani SP, Sankaranarayanan R, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1662-4. Epub 2004, Aug 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15333948 15333948]
[[Category: Pyrococcus abyssi]]
[[Category: Pyrococcus abyssi]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Editing domain]]
[[Category: Editing domain]]
[[Category: Trna-synthetase]]
[[Category: Trna-synthetase]]
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