27gz: Difference between revisions
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The | ==Juvenile hormone binding protein complexed with 2-Methyl-1-(4-butylbenzyl)-benzimidazole== | ||
<StructureSection load='27gz' size='340' side='right'caption='[[27gz]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[27gz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=27GZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=27GZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1MHI:1-[(4-butylphenyl)methyl]-2-methyl-benzimidazole'>A1MHI</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=27gz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=27gz OCA], [https://pdbe.org/27gz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=27gz RCSB], [https://www.ebi.ac.uk/pdbsum/27gz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=27gz ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9U556_BOMMO Q9U556_BOMMO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The authors previously reported that 2-methylbenzimidazole derivatives (MBIs) exhibit insect growth-regulating activity against the silkworm, Bombyx mori. However, despite their unique effects on juvenile hormone (JH)-related endocrine pathways, the precise mode of action of MBIs remained unclear. In the present study, the interactions between MBIs and the lepidopteran hemolymph JH-binding protein (JHBP), a key regulator of JH transport and activity, were investigated using multiple approaches, including in vitro binding affinity assays, X-ray crystallography, and molecular docking simulations. A series of MBIs bearing a 1-(4-alkoxybenzyl) group, which exhibited potent insect growth-regulating activity, showed high binding affinity and structural compatibility with the JH-binding pocket of JHBP. In contrast, 1-(4-alkylbenzyl) MBIs, which displayed weak or negligible insect growth-regulating activity, exhibited low affinity for JHBP. These findings suggest that the insect growth-regulating activity of MBIs is mediated through inhibition of JHBP function, likely by disrupting the precise regulation of JH concentration in the hemolymph during larval development and pupal metamorphosis. | |||
Structural Characteristics for the Interaction of 1-Benzyl-2-Methylbenzimidazoles as Insect Growth Regulators and Juvenile Hormone Binding Protein.,Gunasekara UKDSS, Inoue K, Fujimoto Z, Henmi S, Tsuchiya W, Suzuki R, Kutsuwada K, Ikeda I, Yamazaki T, Shiotsuki T Insects. 2026 Jun 22;17(6):657. doi: 10.3390/insects17060657. PMID:42355390<ref>PMID:42355390</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 27gz" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Shiotsuki | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Bombyx mori]] | |||
[[Category: Large Structures]] | |||
[[Category: Fujimoto Z]] | |||
[[Category: Shiotsuki T]] | |||
[[Category: Suzuki R]] | |||
[[Category: Tsuchiya W]] | |||
