1y6d: Difference between revisions

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[[Image:1y6d.gif|left|200px]]
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[[Image:1y6d.png|left|200px]]


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{{STRUCTURE_1y6d|  PDB=1y6d  |  SCENE=  }}  
{{STRUCTURE_1y6d|  PDB=1y6d  |  SCENE=  }}  


'''Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing'''
===Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing===




==Overview==
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The marine bacterium Vibrio harveyi controls its bioluminescence by a process known as quorum sensing. In this process, autoinducer molecules are detected by membrane-bound sensor kinase/response regulator proteins (LuxN and LuxQ) that relay a signal via a series of protein phosphorylation reactions to another response regulator protein, LuxO. Phosphorylated LuxO indirectly represses the expression of the proteins responsible for bioluminescence. Integral to this quorum sensing process is the function of the phosphotransferase protein, LuxU. LuxU acts to shuttle the phosphate from the membrane-bound proteins, LuxN and LuxQ, to LuxO. LuxU is a 114 amino acid residue monomeric protein. Solution NMR was used to determine the three-dimensional structure of LuxU. LuxU contains a four-helix bundle topology with the active-site histidine residue (His58) located on alpha-helix C and exposed to solution. The active site represents a cluster of positively charged residues located on an otherwise hydrophobic protein face. NMR spin-relaxation experiments identify a collection of flexible residues localized on the same region of LuxU as His58. The studies described here represent the first structural characterization of an isolated, monomeric bacterial phosphotransferase protein.
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{{ABSTRACT_PUBMED_15740742}}


==About this Structure==
==About this Structure==
1Y6D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6D OCA].  
1Y6D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y6D OCA].  


==Reference==
==Reference==
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[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
[[Category: Quorum sensing]]
[[Category: Quorum sensing]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:55:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:31:07 2008''

Revision as of 13:31, 29 July 2008

File:1y6d.png

Template:STRUCTURE 1y6d

Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing

Template:ABSTRACT PUBMED 15740742

About this Structure

1Y6D is a Single protein structure of sequence from Vibrio harveyi. Full experimental information is available from OCA.

Reference

Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing., Ulrich DL, Kojetin D, Bassler BL, Cavanagh J, Loria JP, J Mol Biol. 2005 Mar 25;347(2):297-307. PMID:15740742

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