Resistosome: Difference between revisions
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The hexameric structure enables NRC4 to act directly as a Ca<sup>2+</sup> channel, thus creating a direct mechanistic link between pathogen detection and defense execution through cell death. The discovery of a second, inhibited state highlights a structural mechanism for tight regulation of immune activation. These findings advance understanding of how plant immune receptors regulate robust cellular responses by modulating their own assembly and membrane channel activity. The unique topology also sets NRC4 apart from pentameric or tetrameric resistosomes and indicates diverse evolutionary strategies for NLR family immune receptors. Additionally, understanding of activation and channel formation of the resistosomes may help to design crops with enhanced resistance to pathogens. | The hexameric structure enables NRC4 to act directly as a Ca<sup>2+</sup> channel, thus creating a direct mechanistic link between pathogen detection and defense execution through cell death. The discovery of a second, inhibited state highlights a structural mechanism for tight regulation of immune activation. These findings advance understanding of how plant immune receptors regulate robust cellular responses by modulating their own assembly and membrane channel activity. The unique topology also sets NRC4 apart from pentameric or tetrameric resistosomes and indicates diverse evolutionary strategies for NLR family immune receptors. Additionally, understanding of activation and channel formation of the resistosomes may help to design crops with enhanced resistance to pathogens. | ||
== Resistosome 3D structures == | |||
[[Resistosome 3D structures]] | |||
== References == | == References == | ||
