1y7x: Difference between revisions

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[[Image:1y7x.gif|left|200px]]
{{Seed}}
[[Image:1y7x.png|left|200px]]


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{{STRUCTURE_1y7x|  PDB=1y7x  |  SCENE=  }}  
{{STRUCTURE_1y7x|  PDB=1y7x  |  SCENE=  }}  


'''Solution structure of a two-repeat fragment of major vault protein'''
===Solution structure of a two-repeat fragment of major vault protein===




==Overview==
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Major vault protein (MVP) is the main constituent of vaults, large ribonucleoprotein particles implicated in resistance to cancer therapy and correlated with poor survival prognosis. Here, we report the structure of the main repeat element in human MVP. The approximately 55 amino acid residue MVP domain has a unique, novel fold that consists of a three-stranded antiparallel beta-sheet. The solution NMR structure of a two-domain fragment reveals the interdomain contacts and relative orientations of the two MVP domains. We use these results to model the assembly of 672 MVP domains from 96 MVP molecules into the ribs of the 13MDa vault structure. The unique features include a thin, skin-like structure with polar residues on both the cytoplasmic and internal surface, and a pole-to-pole arrangement of MVP molecules. These studies provide a starting point for understanding the self-assembly of MVP into vaults and their interactions with other proteins. Chemical shift perturbation studies identified the binding site of vault poly(ADP-ribose) polymerase, another component of vault particles, indicating that MVP domains form a new class of interaction-mediating modules.
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{{ABSTRACT_PUBMED_16373071}}


==Disease==
==Disease==
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==About this Structure==
==About this Structure==
1Y7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA].  
1Y7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y7X OCA].  


==Reference==
==Reference==
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[[Category: Beta-sheet module]]
[[Category: Beta-sheet module]]
[[Category: Structural repeat]]
[[Category: Structural repeat]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:58:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:08:18 2008''

Revision as of 00:08, 29 July 2008

File:1y7x.png

Template:STRUCTURE 1y7x

Solution structure of a two-repeat fragment of major vault protein

Template:ABSTRACT PUBMED 16373071

Disease

Known disease associated with this structure: Mitral valve prolapse, myxomatous 1 OMIM:[157700]

About this Structure

1Y7X is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of a two-repeat fragment of major vault protein., Kozlov G, Vavelyuk O, Minailiuc O, Banville D, Gehring K, Ekiel I, J Mol Biol. 2006 Feb 17;356(2):444-52. Epub 2005 Dec 7. PMID:16373071

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