36je: Difference between revisions
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==Crystal structure of Yck2 from Candida albicans in complex with kinase inhibitor MN-II-70: N-(4-(2-(4-fluorophenyl)-6-methylpyrazolo[1,5-a]pyridin-3-yl)pyridin-2-yl)acetamide== | |||
<StructureSection load='36je' size='340' side='right'caption='[[36je]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[36je]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=36JE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=36JE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1DLP:~{N}-[4-[2-(4-fluorophenyl)-6-methyl-pyrazolo[1,5-a]pyridin-3-yl]pyridin-2-yl]ethanamide'>A1DLP</scene></td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=36je FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=36je OCA], [https://pdbe.org/36je PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=36je RCSB], [https://www.ebi.ac.uk/pdbsum/36je PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=36je ProSAT]</span></td></tr> | ||
[[ | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/YCK2_CANAL YCK2_CANAL] Serine/threonine protein kinase required to cause normal damage to epithelial cells and resist antimicrobial peptides.<ref>PMID:19700637</ref> | ||
[[Category: | == References == | ||
[[Category: Lemak | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Satchell | </StructureSection> | ||
[[Category: Savchenko | [[Category: Candida albicans SC5314]] | ||
[[Category: Large Structures]] | |||
[[Category: Cowen LE]] | |||
[[Category: Joachimiak A]] | |||
[[Category: Lemak S]] | |||
[[Category: Prive GG]] | |||
[[Category: Satchell KJF]] | |||
[[Category: Savchenko A]] | |||
[[Category: Stogios PJ]] | |||
[[Category: Williams A]] | |||
Latest revision as of 04:58, 19 August 2026
Crystal structure of Yck2 from Candida albicans in complex with kinase inhibitor MN-II-70: N-(4-(2-(4-fluorophenyl)-6-methylpyrazolo[1,5-a]pyridin-3-yl)pyridin-2-yl)acetamide
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