1y91: Difference between revisions

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[[Image:1y91.gif|left|200px]]
{{Seed}}
[[Image:1y91.png|left|200px]]


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{{STRUCTURE_1y91|  PDB=1y91  |  SCENE=  }}  
{{STRUCTURE_1y91|  PDB=1y91  |  SCENE=  }}  


'''Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor'''
===Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor===




==Overview==
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The protein structure guided design of a series of pyrazolo[1,5-a]pyrimidines with high potency for human cyclin-dependent kinase 2 (CDK2) is described. Some examples were shown to inhibit the growth of human colon tumour cells, were equipotent for CDK1 and were selective against GSK-3beta and other kinases.
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{{ABSTRACT_PUBMED_15686876}}


==About this Structure==
==About this Structure==
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[[Category: Pyrazolopyrimidine inhibitor]]
[[Category: Pyrazolopyrimidine inhibitor]]
[[Category: Serine/threonine protein kinase]]
[[Category: Serine/threonine protein kinase]]
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