1ya3: Difference between revisions

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[[Image:1ya3.~~gif~~|left|200px]]

[[Image:1ya3.png|left|200px]]

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~~'''~~Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension~~'''~~

===Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension===

~~==Overview==~~

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The ~~S810L mutation within~~ the ~~human mineralocorticoid receptor~~ (~~MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist~~. ~~Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs~~. ~~These structures~~, the ~~first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15908963}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15908963 is the PubMed ID number.

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==About this Structure==

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[[Category: Nuclear receptor transcription regulation]]

[[Category: Steroid receptor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 16~~:03:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:50:39 2008''

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-[[Image:1ya3.gif|left|200px]]
+{{Seed}}
+[[Image:1ya3.png|left|200px]]
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 {{STRUCTURE_1ya3|  PDB=1ya3  |  SCENE=  }}
-'''Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension'''
+===Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to progesterone and harboring the S810L mutation responsible for a severe form of hypertension===
-==Overview==
+<!--
-The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.
+The line below this paragraph, {{ABSTRACT_PUBMED_15908963}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15908963 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15908963}}
 ==About this Structure==
@@ Line 33: / Line 37: @@
 [[Category: Nuclear receptor transcription regulation]]
 [[Category: Steroid receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:03:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:50:39 2008''