1ya7: Difference between revisions

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[[Image:1ya7.gif|left|200px]]
{{Seed}}
[[Image:1ya7.png|left|200px]]


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{{STRUCTURE_1ya7|  PDB=1ya7  |  SCENE=  }}  
{{STRUCTURE_1ya7|  PDB=1ya7  |  SCENE=  }}  


'''Implications for interactions of proteasome with PAN and PA700 from the 1.9 A structure of a proteasome-11S activator complex'''
===Implications for interactions of proteasome with PAN and PA700 from the 1.9 A structure of a proteasome-11S activator complex===




==Overview==
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Proteasomes are cylindrical structures that function in multiple cellular processes by degrading a wide variety of cytosolic and nuclear proteins. Substrate access and product release from the enclosed catalytic chamber occurs through axial pores that are opened by activator complexes. Here, we report high-resolution structures of wild-type and mutant archaeal proteasomes bound to the activator PA26. These structures support the proposal that an ordered open conformation is required for proteolysis and that its formation can be triggered by outward displacement of surrounding residues. The structures and associated biochemical assays reveal the mechanism of binding, which involves an interaction between the PA26 C terminus and a conserved lysine. Surprisingly, biochemical observations implicate an equivalent interaction for the unrelated ATP-dependent activators PAN and PA700.
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{{ABSTRACT_PUBMED_15916965}}


==About this Structure==
==About this Structure==
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[[Category: Open gate]]
[[Category: Open gate]]
[[Category: Pa26]]
[[Category: Pa26]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:03:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:57:33 2008''

Revision as of 06:57, 28 July 2008

File:1ya7.png

Template:STRUCTURE 1ya7

Implications for interactions of proteasome with PAN and PA700 from the 1.9 A structure of a proteasome-11S activator complex

Template:ABSTRACT PUBMED 15916965

About this Structure

1YA7 is a Protein complex structure of sequences from Thermoplasma acidophilum and Trypanosoma brucei. Full crystallographic information is available from OCA.

Reference

The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions., Forster A, Masters EI, Whitby FG, Robinson H, Hill CP, Mol Cell. 2005 May 27;18(5):589-99. PMID:15916965

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