1yae: Difference between revisions

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[[Image:1yae.gif|left|200px]]
{{Seed}}
[[Image:1yae.png|left|200px]]


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{{STRUCTURE_1yae|  PDB=1yae  |  SCENE=  }}  
{{STRUCTURE_1yae|  PDB=1yae  |  SCENE=  }}  


'''Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid'''
===Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid===




==Overview==
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We report the crystal structure of the glycosylated ligand-binding (S1S2) domain of the kainate receptor subunit GluR6, in complex with the agonist domoate. The structure shows the expected overall homology with AMPA and NMDA receptor subunit structures but reveals an unexpected binding mode for the side chain of domoate, in which contact is made to the larger lobe only (lobe I). In common with the AMPA receptor subunit GluR2, the GluR6 S1S2 domain associates as a dimer, with many of the interdimer contacts being conserved. Subtle differences in these contacts provide a structural explanation for why GluR2 L483Y and GluR3 L507Y are nondesensitizing, but GluR6, which has a tyrosine at that site, is not. The structure incorporates native glycosylation, which has not previously been described for ionotropic glutamate receptors. The position of the sugars near the subunit interface rules out their direct involvement in subunit association but leaves open the possibility of indirect modulation. Finally, we observed several tetrameric assemblies that satisfy topological constraints with respect to connection to the receptor pore, and which are therefore candidates for the native quaternary structure.
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{{ABSTRACT_PUBMED_15677325}}


==About this Structure==
==About this Structure==
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[[Category: Glutamate receptor]]
[[Category: Glutamate receptor]]
[[Category: Kainate receptor]]
[[Category: Kainate receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:04:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:36:15 2008''

Revision as of 05:36, 28 July 2008

File:1yae.png

Template:STRUCTURE 1yae

Structure of the Kainate Receptor Subunit GluR6 Agonist Binding Domain Complexed with Domoic Acid

Template:ABSTRACT PUBMED 15677325

About this Structure

1YAE is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid., Nanao MH, Green T, Stern-Bach Y, Heinemann SF, Choe S, Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1708-13. Epub 2005 Jan 26. PMID:15677325

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