1yc1: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1yc1.gif|left|200px]]
{{Seed}}
[[Image:1yc1.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1yc1|  PDB=1yc1  |  SCENE=  }}  
{{STRUCTURE_1yc1|  PDB=1yc1  |  SCENE=  }}  


'''Crystal Structures of human HSP90alpha complexed with dihydroxyphenylpyrazoles'''
===Crystal Structures of human HSP90alpha complexed with dihydroxyphenylpyrazoles===




==Overview==
<!--
A series of dihydroxyphenylpyrazole compounds were identified as a unique class of reversible Hsp90 inhibitors. The crystal structures for two of the identified compounds complexed with the N-terminal ATP binding domain of human Hsp90alpha were determined. The dihydroxyphenyl ring of the compounds fits deeply into the adenine binding pocket with the C2 hydroxyl group forming a direct hydrogen bond with the side chain of Asp93. The pyrazole ring forms hydrogen bonds to the backbone carbonyl of Gly97, the hydroxyl group of Thr184 and to a water molecule, which is present in all of the published HSP90 structures. One of the identified compounds (G3130) demonstrated cellular activities (in Her-2 degradation and activation of Hsp70 promoter) consistent with the inhibition of cellular Hsp90 functions.
The line below this paragraph, {{ABSTRACT_PUBMED_15713410}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15713410 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15713410}}


==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Cell-cycle]]
[[Category: Cell-cycle]]
[[Category: Drug design]]
[[Category: Drug design]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:07:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:45:35 2008''
Retrieved from "https://proteopedia.org/1yc1"