1yee: Difference between revisions

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[[Image:1yee.~~gif~~|left|200px]]

[[Image:1yee.png|left|200px]]

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~~'''~~STRUCTURE OF A CATALYTIC ANTIBODY, IGG2A FAB FRAGMENT (D2.5)~~'''~~

===STRUCTURE OF A CATALYTIC ANTIBODY, IGG2A FAB FRAGMENT (D2.5)===

~~==Overview==~~

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The ~~x-ray structures of three esterase-like catalytic antibodies identified by screening for catalytic activity~~ the ~~entire hybridoma repertoire, elicited in response~~ to ~~a phosphonate transition state analog~~ (~~TSA) hapten, were analyzed~~. ~~The high resolution structures account for catalysis by transition state stabilization, and in all three antibodies a tyrosine residue participates in the oxyanion hole~~. ~~Despite significant conformational differences in their combining sites, the three antibodies~~, ~~which are~~ the most efficient among those elicited, achieve catalysis in essentially the same mode, suggesting that evolution for binding to a single TSA followed by screening for catalysis lead to antibodies with structural convergence.

The line below this paragraph, {{ABSTRACT_PUBMED_9027317}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9027317 is the PubMed ID number.

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==About this Structure==

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[[Category: Catalytic antibody]]

[[Category: Transition state analogue]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 16~~:13:15 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:17:46 2008''

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-[[Image:1yee.gif|left|200px]]
+{{Seed}}
+[[Image:1yee.png|left|200px]]
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 {{STRUCTURE_1yee|  PDB=1yee  |  SCENE=  }}
-'''STRUCTURE OF A CATALYTIC ANTIBODY, IGG2A FAB FRAGMENT (D2.5)'''
+===STRUCTURE OF A CATALYTIC ANTIBODY, IGG2A FAB FRAGMENT (D2.5)===
-==Overview==
+<!--
-The x-ray structures of three esterase-like catalytic antibodies identified by screening for catalytic activity the entire hybridoma repertoire, elicited in response to a phosphonate transition state analog (TSA) hapten, were analyzed. The high resolution structures account for catalysis by transition state stabilization, and in all three antibodies a tyrosine residue participates in the oxyanion hole. Despite significant conformational differences in their combining sites, the three antibodies, which are the most efficient among those elicited, achieve catalysis in essentially the same mode, suggesting that evolution for binding to a single TSA followed by screening for catalysis lead to antibodies with structural convergence.
+The line below this paragraph, {{ABSTRACT_PUBMED_9027317}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9027317 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9027317}}
 ==About this Structure==
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 [[Category: Catalytic antibody]]
 [[Category: Transition state analogue]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:13:15 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:17:46 2008''