32jd: Difference between revisions
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==Structure of the pathogenic variant P157S of Human SHMT2 in a distorted tetrameric conformation== | |||
<StructureSection load='32jd' size='340' side='right'caption='[[32jd]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[32jd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=32JD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=32JD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=32jd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=32jd OCA], [https://pdbe.org/32jd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=32jd RCSB], [https://www.ebi.ac.uk/pdbsum/32jd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=32jd ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Di Matteo | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/GLYM_HUMAN GLYM_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.<ref>PMID:21876188</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Boumis G]] | |||
[[Category: Breccia S]] | |||
[[Category: Di Matteo A]] | |||
[[Category: Giardina G]] | |||
Latest revision as of 16:45, 8 September 2026
Structure of the pathogenic variant P157S of Human SHMT2 in a distorted tetrameric conformation
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