9tyv: Difference between revisions

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'''Unreleased structure'''


The entry 9tyv is ON HOLD  until Paper Publication
==Cryo-EM Structure of Human TMEM45B==
<StructureSection load='9tyv' size='340' side='right'caption='[[9tyv]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9tyv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TYV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.82&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1KB5:5-acetamido-2-[2-(hydroxymethyl)-6-[(2~{R},3~{S},4~{R},5~{R},6~{R})-2-(hydroxymethyl)-4,5-bis(oxidanyl)-6-[(~{E},2~{S},3~{R})-3-oxidanyl-2-(tetracos-14-enoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-4-oxidanyl-6-[1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic+acid'>A1KB5</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tyv OCA], [https://pdbe.org/9tyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tyv RCSB], [https://www.ebi.ac.uk/pdbsum/9tyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tyv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TM45B_HUMAN TM45B_HUMAN] Plays a role in innate immunity (PubMed:35938871). Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral RNA and nsP1 (PubMed:35938871). Essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity (By similarity).[UniProtKB:Q8VCZ2]<ref>PMID:35938871</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The orphan transmembrane protein 45B (TMEM45B) has been reported to be involved in mechanical pain hypersensitivity, antiviral processes, and cancer. The structure of human TMEM45B with bound monosialodihexosylganglioside (GM3, 18:1;O2/24:1), presented here, determined by single-particle cryo-electron microscopy (cryo-EM) to 2.8 A, reveals a homotetrameric assembly of seven-transmembrane-helix protomers. The first six transmembrane helices from each protomer create a central hydrophobic tunnel that accommodates metal ions and the C24:1 fatty acid component of the ganglioside GM3.


Authors: Grieben, M.
Cryo-EM structure of human TMEM45B with a bound GM3 (18:1;O2/24:1).,Grieben M, Inderhees J, Ebersberger N J Struct Biol. 2026 Sep 24;218(4):108376. doi: 10.1016/j.jsb.2026.108376. PMID:42785650<ref>PMID:42785650</ref>


Description: Cryo-EM Structure of Human TMEM45B
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Grieben, M]]
<div class="pdbe-citations 9tyv" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Grieben M]]
[[Category: Inderhees J]]
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